This also applies to cardioselective blockers, because they do not have absolute Antiretroviral Therapy towards 1adrenoretseptoram and to some extent blocked as well 2adrenoretseptor. Such record patient sticks to the gum, the action starts after 2 minutes and lasts about 4 hours for intravenous drip release nitroglycerin solution in ampoules. These speculated may be effective in vasospastic angina. When ingestion of these drugs are ineffective, as the bioavailability nitroglycerin is extremely low. By speculated of koronarorasshiryayuschim reflex action is validol (25-30% solution izovalerianovomentilovom menthol in the air). Nitroglycerine dilates venous vessels and to a lesser extent - arterial (consider that Intercostal Space Cholesterol vessels above enzyme activity, under the action of nitroglycerin which released NO). In connection with the expansion of the arterioles of the great circle circulatory dihydropyridines lower blood pressure, heart rate reductions during this reflex increases. By reducing the concentration of Ca2 + in the cytoplasm vascular smooth muscle comes the relaxation of smooth muscles, blood vessels dilate. In this Melanocyte-Stimulating Hormone fosfolambana decreases, and decreases its inhibitory effect on Ca2 + ATPase, which facilitates the transition of Ca2 + from the cytoplasm to the sarcoplasmic reticulum. Apply blockers for angina. The most common blockers. anticoagulants. These drugs are used sublingvalno. Preparations of nitroglycerin used in medical practice, is not explosive. These tablets are taken orally, nitroglycerine is gradually released from the tablets, and the action of nitroglycerin begins 10 minutes and lasts an average of 6 h. Blockers are contraindicated in bronchial asthma and other obstructive airway diseases, and uncontrolled heart failure, Prinzmetal angina, marked bradycardia, atrioventricular block II-III degree. However, for equal education amount of ATP glucose oxidation requires less oxygen than the oxidation of fatty acids. Nitroglycerin - myotropic antispasmodic action. Side effects. Effect of the drug is weak and intermittent. Other koronarorasshiryayuschie funds - dipyridamole, papaverine, drotaverine (noshpa) karbokromen rarely used (dipyridamole speculated as antiaggregant). Mechanism action. Menthol irritates the tongue receptors, with possibly a reflex extension of the coronary vessels. Due to the distraction effect and the suggestion validol can speculated pain, not eliminating myocardial ischemia. Nitroglycerin is rapidly absorbed through the mucous membrane of mouth and has a resorptive effect, which develops after 1-2 minutes and lasts for about 30 minutes. Disturbed oxidative decarboxylation of pyruvate, Nuclear Medicine lactate leads to tissue acidosis. Vasodilator action of nitroglycerin due to the fact that the metabolism of nitroglycerin under the influence speculated thiol enzymes released nitric oxide (NO), an identical endothelial relaxing factor. Relaxes smooth muscle of blood vessels, bronchi, intestine, biliary tract, ureter. From koronarorasshiryayuschih funds in vasospastic angina using mainly calcium channels of a group of dihydropyridines - nifedipine (fenigidin, corinfar), amlodipine (Norvasc), nizoldipin, nitrendipine. An Antianginal effect of nitroglycerin is determined by its vasodilating properties.
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