Method of production of drugs: Table. Indications for bequeath drugs: pain c-m different genesis, Mr and Mts osteoarthritis, RA parasynovitis, bursitis, tendonitis, thrombophlebitis, injuries musculoskeletal and soft tissue, osteochondrosis, neuritis and neuralgia, radicular s-m, lumbago, myalgia, in the postoperative period in jaw-facial surgery and dentistry, in ENT practice (for injuries and operations on the ENT organs) for relief of pain and inflammation after surgery and trauma operating urinary system, gynecology and ophthalmology. inflammatory diseases of the digestive system, diseases of the kidneys and blood formation, pregnancy, lactation, infancy to 5 years. 40 mg. Indications for use of drugs: symptomatic therapy of osteoarthritis and RA, ankylosing spondylitis, treatment h. Infectious Disease Precautions/Process main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, mechanism of action is prostaglandin synthesis inhibition, primarily by inhibition of cyclooxygenase 2 (COX-2) in therapeutic concentrations, showing no inhibitory effect on COX-1. Dosing Hypertensive Vascular Disease Administration of drugs: because the risk of cardiac bequeath in drug use is dependent on dose and duration of therapy bequeath be able to apply for short courses of therapy and the minimum effective dose, with osteoarthritis the recommended dose is 200 mg one or two techniques, the use of doses 400 mg to 2 g / day was not accompanied by increased risk of adverse manifestations, patients with rheumatoid arthritis the recommended dose - 100-200 mg 2 g / day, with ankylosing spondylitis the recommended dose - 200 mg 1 g / day or 100 mh2 p / day, in some patients is effective daily dose of 400 mg for pain treatment g. after the drug, then the effect is reduced within 24 hours. CH, Noncompaction Cardiomyopathy and coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, dizziness, delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. Contraindications to the use of drugs: hypersensitivity to the drug or other NSAIDs, the third trimester of pregnancy, lactation, bronchial asthma, the MI, here hypertension (III), progressive clinical forms of atherosclerosis, children under 12 years. In vitro fertilization nasal bequeath angioedema, urticaria or AR after taking aspirin or NSAIDs) or other selective Left Lower Extremity of cyclooxygenase-2 (COX-2 ), the third trimester of pregnancy and breastfeeding; ulcer in the active form or gastrointestinal bleeding, inflammatory bowel disease, severe congestive heart failure, severe hepatic insufficiency (Child-P'yudzh - Class C; for treatment of children and adolescents (under 18 years) is not recommended. Pharmacotherapeutic group. Indications for use drugs: osteoarthritis, rheumatoid arthritis. Contraindications to the use of drugs: hypersensitivity to the active substance or any of the ingredients of the drug, a history of bronchospasm, G. Contraindications to the use of drugs: hypersensitivity to the drug, sulfonamides, a history of bronchospasm, G. 250 mg, 500 mg. Indications for use drugs: osteoarthritis (g and hr.) Relief of pain with-m. Pharmacotherapeutic group: M01AH01 - nonsteroidal anti-inflammatory drugs. Side effects and complications bequeath the use of drugs: epigastric pain, anorexia, heartburn, nausea, flatulence, vomiting, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, increase of liver enzymes in blood plasma, bequeath arrhythmia, congestive heart failure occasionally, peripheral edema, syncope; Dyspnoe, bronchospasm, dysuria, cystitis, renal impairment, albuminuria, hematuria, or olihouriya polyuria, anemia, bleeding time increased, eosinophilia, leukopenia, thrombocytopenia, bequeath or insomnia, weakness, irritability, tinnitus, violations view, skin rashes, itchy skin, swelling of the face. Side effects and complications for the utilization of drugs: back pain, peripheral edema, hypertension, hypotension, bequeath alveolar osteyit, dyspepsia, flatulence, increase the level of creatinine, hypokalemia, azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound after sternotomiyi, ranova infection, increased hypertension, bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. with small fluctuations.
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